Validation


There were two stages in the development of the SAQ.


  • In the first stage patients with severe asthma were interviewed and domains of quality of life deficit identified1.
  • In the second stage, information from these interviews was used to construct a questionnaire and then patients in focus groups evaluated the questionnaire and suggested changes to wording2. Because of this additional qualitative stage, the SAQ is optimised to the content and wording of severe asthma patients.

Initial quantitative validation has been completed and includes test re-test reliability3. Large scale studies are in train and include comparison with other HRQoL scales, sensitivity to change, and minimally clinically important difference. Domain scoring will be published later.


  1. Hyland ME, Whalley B, Jones RC, Masoli M. A qualitative study of the impact of severe asthma and its treatment showing that treatment burden is neglected in existing asthma assessment scales. Quality of Life Research. 2015;24:631-9.
  2. Hyland ME, Lanario JW, Pooler J, Masoli M, Jones RC. How patient participation was used to develop a questionnaire that is fit for purpose for assessing quality of life in severe asthma. Health and quality of life outcomes. 2018;16(1):24. https://doi.org/10.1186/s12955-018-0851-9
  3. Paper submitted, currently under review.